4 Differences between Sculptra and Radiesse Fillers

The major difference between Sculptra and Radiesse lies in their composition, mechanism of action, and the specific aesthetic concerns they address.

What’s the differences between Sculptra and Radiesse?


  • Sculptra: Sculptra filler contains poly-L-lactic acid, a biocompatible synthetic substance. It is in the form of microspheres that stimulate collagen production in the skin over time.
  • RADIESSE: RADIESSE filler consists of calcium hydroxyapatite microspheres suspended in a gel-like substance. Calcium hydroxyapatite is a mineral-like compound found in bones, making it biocompatible and safe for use.

Mechanism of Action:

  • Sculptra: Sculptra filler works by stimulating collagen production in the skin. The poly-L-lactic acid microspheres trigger a natural response, leading to increased collagen synthesis over several weeks and months. The gradual collagen buildup improves skin texture, volume, and reduces the appearance of wrinkles and folds.
  • RADIESSE: RADIESSE filler provides an immediate volumizing effect due to the calcium hydroxyapatite microspheres that add instant volume upon injection. In addition to the immediate results, RADIESSE also stimulates collagen production, enhancing the skin’s structure and elasticity over time.

Treatment Areas:

  • Sculptra: Sculptra is primarily used for restoring volume and addressing signs of facial aging, such as sunken cheeks, temples, and loss of volume in the mid-face. It is also effective in treating wrinkles, folds, and lines, providing overall facial rejuvenation.
  • RADIESSE: RADIESSE filler is commonly used to add volume, contour, and lift various areas of the face, including the cheeks, jawline, chin, and temples. It is also suitable for improving the appearance of nasolabial folds, marionette lines, and other facial wrinkles. Additionally, RADIESSE can be used for hand rejuvenation, restoring volume and minimizing the visibility of tendons and veins.

Duration of Results:

  • Sculptra: Sculptra offers long-lasting results that can last up to two years. The gradual collagen stimulation leads to a gradual improvement in the skin’s appearance over time.
  • RADIESSE: RADIESSE results typically last up to a year or more, depending on the individual and the treatment area. The immediate volumizing effect is complemented by the long-term benefits of collagen stimulation.

Which is better? Sculptra or Radiesse?

It’s important to note that both Sculptra and Radiesse should be administered by experienced and qualified practitioners to ensure optimal results and minimize risks. Consulting with a skilled professional like Dr. Ahmad Othman, Specialist Dermatologist at Derma One Dubai can help determine which filler is best suited to address your specific concerns and achieve your desired outcome.